Promethazine with Codeine Oral Remedy need to be utilized with caution in patients with bone-marrow despair. Leukopenia and agranulocytosis are already noted, usually when promethazine has long been Utilized in Affiliation with other recognized marrow-toxic brokers.

This medication has been prescribed to your latest issue only. Never utilize it later on for one more issue Except informed to take action by your health practitioner. A distinct medication may very well be needed in These cases.

Using this medication with any of the subsequent medicines isn't proposed. Your medical doctor might make your mind up not to treat you using this type of medication or change many of the other medicines you are taking.

A Health care Specialist ought to be consulted before having any drug, modifying any diet plan or commencing or discontinuing any course of cure.

This item may well have inactive ingredients, which often can induce allergic reactions or other issues. Speak to your pharmacist for more particulars.

notify your health care provider For those who have or have at any time experienced an enlarged prostate (a male reproductive gland); glaucoma (a issue in which greater strain in the attention can cause gradual lack of vision); seizures; ulcers; blockage inside the passage between the stomach and intestine; blockage while in the bladder; bronchial asthma or other lung disease; snooze apnea; most cancers;any affliction that influences the creation of blood cells in your bone marrow; or heart or liver condition.

Drug interactions may well alter how your prescription drugs function or increase your threat for significant Unwanted side effects. This doc would not comprise all feasible drug interactions.

Use with caution in patients with fundamental intestinal motility Issues. The codeine in Promethazine with Codeine Oral Remedy may cause spasm of your sphincter of Oddi, causing an increase in biliary tract force. Opioids may perhaps cause raises in serum amylase [seeWARNINGS AND Safeguards (5.21)]. Keep track of people with biliary tract disease, like acute pancreatitis Promethazine codeine syrup for worsening signs. Administration of promethazine has become related to documented cholestatic jaundice.

The subsequent major adverse reactions are described, or explained in higher depth, in other sections:

You'll want to Adhere to the directions diligently, since continuing constipation can lead to extra severe challenges.

Acute or extreme bronchial bronchial asthma within an unmonitored location or in absence of resuscitative gear. (four)

program to stay away from unneeded or extended exposure to daylight also to wear protective apparel, sunglasses, and sunscreen. Promethazine may perhaps make your skin delicate to sunlight.

Utilization of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with Promethazine with Codeine Oral Solution demands careful consideration of the results over the mother or father drug, codeine, plus the Energetic metabolite, morphine.

Codeine was not mutagenic while in the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.